Tablet press pine chips and lobes?
by:Jinzong Machinery
2021-04-16
Tablet press pine chips and lobes?
(
A total of five -
-
2)
(
ZP - is illustrated below
9 rotary tablet press)
ZP -
9 rotary tablet press video watching, please click: Jin Zonghe home ning, chairman of answer: a: tablet press the cause and the process is as follows: the loose piece of loose after refers to the tablet press into the hardness is not enough, the surface has a hole, a finger gently pressure is broken.
1.
Pressure is not enough.
Solution: increase the pressure.
However, for some special purpose of huge demand pressure, the pressure to achieve tablet press pressure cap or beyond the limit, need to customize pressure corresponding specifications of the tablet press.
2.
Pressure too little time, rotational speed is fast.
Corresponding to extend the time pressure, increasing prepressing, reduce speed.
3.
More stamping pieces on board at length.
Solution: adjust the punch.
4.
Loose adjustable head in a threatening manner.
To tighten.
5.
Drugs are not reaching grinding fineness, fibrous or elastic drugs or uneven oil component content and more mixed.
Drugs can be shattered through 100 mesh sieve, choose the viscosity strong adhesive, increasing the pressure of the tablet press, increase oil drug absorption agent fully blending method to overcome it.
6.
Glue or insufficient dosage of wetting agent or improper selection, make irregular particle texture osteoporosis or particle size distribution, coarse and fine particle layer.
Can choose appropriate adhesive or increase consumption, improve the granulating process, mixing soft material, mix both particles such as methods to overcome it.
7.
Grain moisture content too little and too much dry granule has great flexibility, containing water of crystallization of drugs lose more water of crystallization in grain drying process, make the particles crunchy, easy to loose lobes.
So when granulating, according to the different species should be controlled grain moisture content.
Works such as made of particles is too, can be sprayed into the proper amount of dilute ethanol (
50% -
60%)
And tablet after blending.
8.
The nature of the drug itself.
Although density of tablet has certain hardness, but can't afford to the collision and jolt.
Like bismuth nitrate, soda pills tends to produce such as loose phenomenon;
Density is small, liquidity is poor, poor can be pressed and granulating again.
9.
Particles of illiquid, fill in the die particles in the non-uniform.
10.
Has a large particle, debris or blockage grain scraper and the feed opening, filling quantity.
11.
When the feed hopper of the particles for less.
Should the qijia particles make maintain stock inside the hopper.
Two: the cause and management of lobes are as follows: lobes is refers to the tablet by vibration or by placing a split from the waist are called waist, split from the top as the top crack, crack and the top crack always called lobes.
1.
Pressure, particle pressure increase, the expansion degree is also increasing, the adhesion strength of the adhesive can't restrain its expansion, hence the lobes, reducing the pressure processing.
2.
On stamping and die out.
Use long die, gradual wear and tear, cause in accord with die not just, and on the edge with a sharp inward and pressure will not divide evenly to make part of the film pressure is too large, and cause crack or die shape deformation.
3.
Tablet machine speed too fast, tablet compression time is too short, the film suddenly pressure and contraction, then suddenly swelled and undivided.
With the increase of preloading preloading time accordingly.
4.
Improper selection adhesive granulating too little glue, low viscosity is dry particles, powder particles are too much, more dry too hard, can cause disruption is difficult, the one-sided pitting, so add glue should be appropriate;
Such as too many fine powder, can screen out a little;
Grain is too hard, should be rework to granulating and additional disintegrating agent.
5.
Particles undesirable, the soft, fine powder lobes, caused by too much improved method should adjust the concentration and dosage of binder, improve granulating methods to overcome it.
6.
Particles is too dry, containing water of crystallization drugs lose too much cause lobes, solution and loose pieces of the same.
7.
Some crystalline drug, without sufficient crushing.
These drugs can be fully after granulating.
8.
Tablet low room temperature, low humidity, easy to cause lobes, especially the viscosity difference drugs easy to produce.
Adjust temperature and humidity system accordingly.
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