Quality Pharmaceutical produciton equipment

The reactor is a container device widely used in the chemical industry, mainly used to complete the chemical reaction process. It can not only provide the temperature and pressure environment required for the reaction, but also control the reaction conditions by stirring, heating or cooling, so as to achieve efficient chemical conversion. With more than 20 years of experience in reactor design, research and development, and manufacturing, Jinchong Enterprise will introduce in detail the main application fields and importance of the reactor.Chemical Industry In the chemical industry, the reactor is one of the basic equipment for carrying out synthetic reactions. it is organic synthesis or inorganic synthesis, the reactor can provide a stable environment for reactants to promote the progress of the reaction. For example, in the pharmaceutical industry, reactor is used to synthesize active ingredients of drugs; while in plastic manufacturing, it is used for polymerization reactions. Pharmaceutical Industry Many key steps in pharmaceutical industry require the use of reactors to complete. From the synthesis of raw materials to the preparation of intermediates, and then to the formation of final products, reactors are indispensable tools In addition, reactors are also used in the process of biopharmaceuticals, such as the fermentation production of antibiotics. Food Industry The food industry also widely reactors for various processing treatments. For instance, in dairy product production, reactors can be used to heat and mix raw materials; in the preparation of seasonings and additives, reactors play an important role. Agrochemical Industry In the agrochemical industry, reactors are used to prepare fertilizers and pesticides. These chemicals usually need to be under specific conditions, and reactors can provide the required temperature, pressure, and stirring conditions to ensure product quality. Fine Chemical Industry Fine chemical products include surfants, dyes, paints, etc., and the production of these products often requires precise control of reaction conditions. Reactors have become the core equipment in the production of chemicals because they can provide a stable and controllable reaction environment. New Material Research and Development With the development of new material technology, reactors also show great application potential the fields of nanomaterials and composites. They can help scientists simulate industrial production conditions in the laboratory environment, accelerating the process of new material research and development. In, as an important piece of chemical equipment, reactors play an irreplaceable role in various industries. With the advancement of technology, the design and technology of reactors in the future will more advanced and better meet the special needs of different fields.

An emulsifier is a mechanical device widely used in various industries such as food, pharmaceutical, cosmetics, etc., mainly used to mix two or more immiscible liquids to form a stable emulsion. The working principle of the emulsifier is to use the shearing force between the high-speed rotating rotor and stator, so that the liquid material is forcibly sucked in and subjected to strong mechanical shearing and high-frequency hydraulic shearing, so as to achieve the effect of dispersion, homogenization and emulsification. The purpose of this paper is to provide a comprehensive user guide for operators who are new to emulsifiers.1. Basic structure of the emulsifier The emulsifier mainly consists of the following parts: Motor:ides the power source. Drive system: Includes gearboxes and couplings, etc., for transmitting the power from the motor. Working head: Usually consists of one more rotors and corresponding stators, which is the core component in the emulsification process. Container: Choose different capacity and shape containers according to the need to load material to be processed. Control system: Used to adjust the working parameters of the emulsifier, such as speed, time, and temperature, etc. 2. Operation steps of the emulsifier Preparation stage Check whether the equipment is intact and ensure that all connectors are fastened. Clean the working head and container to cross-contamination. Prepare raw materials according to process requirements and preheat (if necessary). Install the working head Install the appropriate model of working head the drive shaft and confirm that it is securely installed. Pre-start check Confirm that the power connection is correct and safe. Check the cooling system (if equipped to ensure it operates normally. Set the parameters on the control panel, such as speed, time, etc. Operation process Start the emulsifier and gradually increase speed to the set value. Observe the changes in the material state and make adjustments when necessary. During the emulsification process, pay attention to the changes in temperature and pressure End and clean-up After completing the emulsification, turn off the equipment and disconnect the power. Clean the working head and container, and perform disinf treatment when necessary.3. Maintenance and Care Regular Inspection: Check the wear and tear of each component of the equipment and replace worn-out parts. Lubrication Maintenance: Lubricate the moving parts according to the manufacturer's recommended schedule. Storage Conditions: Store in a dry and vent place, away from moisture and corrosive gases. IV. Common Issues and Solutions Poor Emulsification Effect: Check if the work head is clogged or; adjust the speed or processing time. Equipment Overheating: Check if the cooling system is functioning properly; reduce load or speed. Excessive Noise: for any foreign objects that may have entered the equipment; tighten any loose parts. Conclusion Proper use and maintenance of the emulsifier can not only improve work but also extend the equipment's lifespan. We hope this guide will help you better master the operation techniques of the emulsifier, providing strong support for your production activities. For technical difficulties encountered in actual application, it is recommended to contact professionals for consultation and resolution promptly. You are also welcome to contact Jinchong Enterprise Consulting.

The reactor is an important equipment used in chemical, pharmaceutical, food and other industries for chemical or physical reactions. Its performance directly affects the quality of products and the safety of production. Therefore, it is very necessary to regularly overhaul the reactor and ensure that it meets certain quality standards. Next, Jin Zong Enterprise, which has more than 20 years of experience in reactor research and development, design and manufacturing, will introduce in detail the overhaul method of the reactor and its related quality standards.Kettle body 1. Replacement conditions The reaction kettle should be replaced if it has been for a certain number of years and one of the following conditions occurs: a. The wall thickness of the kettle body is uniformly corroded and exceeds the minimum value specified the design; b. The wall thickness of the kettle body is locally corroded and exceeds the minimum value specified in the design, and the corroded area is greater 20% of the total area; c. During the hydrostatic test, the equipment has obvious deformation or residual deformation exceeds the specified value; d. to alkali embrittlement or intergranular corrosion, cracks occur in the kettle body or welds and cannot be repaired; e. When the damaged area the porcelain surface exceeds 15% or the damaged part cannot be repaired; f. When there are defects that exceed the standard (such as: serious structural defects endanger safe operation; welds that do not meet the requirements; serious incomplete penetration, cracks, etc.) and cannot be repaired. 2. Steel kettle body a. Local corrosion of the shell shall be repaired by arc welding method, and if the corroded area is large, the patch method shall be used for repair. . Unthreaded cracks. If the depth of the crack is less than 10% of the wall thickness and not more than 1mm, the crack can be flat with a grinding wheel, and it is smooth transition with the metal surface. If the depth of the crack does not exceed 40% of the wall thickness, a be can be chipped out within the depth of the crack, and then it can be welded, but it is better to drill small holes at both ends of the crack to prevent crack from extending. For long cracks, the method of welding from both ends of the crack to the middle should be used (from both ends of the crack to the middle) to the welding stress and deformation. If the depth of the crack exceeds 40% of the wall thickness, it should be treated as a penetrating narrow crack. c Penetrating narrow cracks. Before welding, drill stop holes at both ends of the crack, the hole diameter is slightly larger than the crack width, and the bevel is processed When the wall thickness is less than 12mm, the V-shaped bevel is adopted; when the wall thickness is greater than 12mm, the X- bevel is adopted. During welding, cracks less than 100mm can be welded at one time; when the crack is longer, it is better to weld both ends of the crack to the middle, not to draw a circle, and to use multi-layer welding. Except for the parts with stress concentration, cracks and penetrating narrow on the kettle body are allowed to be repaired. d. Penetrating wide cracks. Wide cracks should be repaired by digging. The length of the dug part should 50 ~ 100mm larger than the length of the crack, and the width should not be less than 250mm. The welded patch should be with the surface of the main body, and the radius of curvature should be the same as that of the main body. e. Stainless steel lining bulge. When lining is deformed on a large area and the height of the lining bulge is less than 0.15 times the average diameter of the deformed area, it is advisable to use water filling pressure method to restore the deformed lining. For shells or linings with small deformation area, mechanical top pressure method can be used for repair, but attention should be paid prevent brittle cracking during the correction process.3. Cast iron kettle body For common defects of cast iron kettle body such as sand holes, cracks, p corrosion or local corrosion, arc cold welding is usually used for repair. When welding, one stop-crack through hole should be drilled at 3-5mm away from each end the crack. 4. Lining glass kettle body Lining glass is brittle and easy to damage, and has poor thermal stability. During maintenance, it necessary to pay attention to the protection of the porcelain surface. It is required to hang or tie the lifting ring or rope at the designated position. Necessary cooling measures should taken during welding. The following repair methods can be used respectively according to different damage conditions. a. Corrosion-resistant metal plugging method. When there are micores on the porcelain surface, corrosion-resistant metal materials can be made into plugs and directly driven into the micropores. b. When the damage of porcelain is slightly larger, corrosion-resistant metal bolts and corrosion-resistant material gaskets are used to fasten the damaged porcelain surface. c. Inorganic coating repair. The surface to be repaired should be cleaned, rusted with 15-20% dilute sulfuric acid, then neutralized with 10% caust soda solution, then washed with water, wiped clean, dried with hot air, and finally inorganic paint is recoated and slowly heated and cured. The weight ratio of the is: flint rock powder: 100, fineness 80-100 mesh; sodium silicate: 5, purity > 95%; glass: 95, specific gravity 1.48. d. Organic coating repair method. The same as inorganic coating repair method. Organic coating weight ratio: Epoxy resin: 100 Dibutyl phthalate: 15 M-phenylenediamine: 2~14 Graphite (or other filler): 50~100. After coating, heat treatment should be carried out at a temperature of80~100℃. The temperature should be slowly increased during heating, and it can be used after full curing. e. The number of clamping for the flange of lining glass kettle body must be kept to the specified standard and evenly distributed. The clamping clips must be symmetrically and evenly tightened along the diagonal, not too much force or once tightened.5. Quality standards for the repair of the kettle body   a. The weld and the base metal should have a smooth.   b. The depth of local undercut on the weld should not exceed 0.5mm, and the length of the undercut connection should not exceed100mm.   c. The weld should be free of cracks, incomplete penetration, incomplete fusion, slag inclusion, and porosity.   . The slag and spatter on the weld should be cleaned up.   e. After repair, no cross welds should appear, and the longitudinal seams between cylinders and between the head and the adjacent cylinder should be staggered, with a spacing greater than three times the thickness of the cylinder and not less than 100mm.   f. The rework of the weld should not exceed twice.   g. The correct material for the electrode should be selected, and the electrode and flux be dried and used as soon as possible.   h. The kettle body after welding must undergo a hydraulic strength test.   When performing the hydraulic strength test the air in the kettle should be completely purged, and the pressure should be slowly increased when the temperature of the kettle wall is close to the temperature of the liquid. pressure should be maintained for 10-30 minutes under the test pressure, and then reduced to the maximum working pressure for inspection. The test is considered successful if there is leakage, no visible abnormal deformation, and no abnormal noise during the test. For kettles with external insulation or those whose appearance cannot be observed, the test should be maintained at maximum working pressure for at least 2 hours, and the test is considered successful if the pressure does not drop and there is no abnormal noise.   i. For kles that require a gas tightness test, the test should be performed after the hydraulic test is successful, and the temperature of the test gas should not be lower than 5℃.Transmission device Triangular belt drive a. When installing and aligning the pulleys, theism of the two pulley axes shall not exceed 0.01a, and the axial displacement of the two wheels' width symmetry plane shall not exceed 0.05a (a is the actual center distance of the two wheels, unit: mm). b. For the fit between the pulley hole and the shaft, H7k6 is selected, and the surface roughness is selected as 1.6/0.8. c. The tension of the triangular belt should be uniform and. d. The pulley should be replaced when there are cracks in the pulley hole, notches in the pulley groove, or serious wear on the groove surface e. The triangular belt should be replaced in case of serious wear; contact between the belt and the bottom of the groove; belt aging; cracks; plastic distortion. f. The triangular belts on the same pulley should be replaced at the same time. Mixing device a. When the mixing shaft is bent, it can be straightened by mechanical pressure method, the straightness of the mixing shaft is 0.10mm/m, and the straightness of the shaft diameter position is .04mm/m. b. When the mixing shaft and the sealing filler are worn, they need to be micro-machined to round, and if the amount is greater than 0.5mm, they should be welded and then machined to restore the dimensions of the drawing. Surface roughness 0.8. c. The mixing blade should be replaced when it is evenly corroded more than 30% of the original thickness. d. For local corrosion, cracks, and of the mixing blade, use welding, shaping, and correction methods for repair. When the enamel mixing blade is damaged by corrosion, chipping, etc., it should be according to the enamel repair method. e. The axis of the paddle, frame, and anchor mixing blades should be perpendicular to the blade, with a perpendicularity of4/1000 of the total length of the blade, and should not exceed 5mm. f. The turbine and propeller mixing blades with a speed than 100r/min should be tested for static balance. Dynamic balance can be achieved by either weight removal or weight addition method, and the thickness of the cut or part should not exceed 1/4 of the wall thickness, and the transition at the junction should be smooth. When the speed is less than 500r/min the unbalanced mass on the outer diameter of the impeller should not exceed 20g. g. For the turbine and propeller mixing blades, the blade hole the mixing shaft neck are selected with H7/k6 fit, and the surface roughness is selected as 1.6/0.8. h. The rolling are disassembled with special tools, and the oil temperature is 140℃ when they are hot-fitted. It is strictly prohibited to heat directly with flame. i. When installing the rolling bearing at the lower end of the mixing shaft, the outer ring should not be pressed to death, and there should be about 0.5-.0mm of axial thermal expansion and contraction allowance. j. The rolling elements and the surface of the raceway of the rolling bearings should be free of corrosion, pits spots, and contact should be smooth without noise. The shaft neck that fits with the inner hole of the rolling bearing is selected with k6, and the surface roughness is .8, and the hole that fits with the outer ring of the rolling bearing is selected with K7, and the surface roughness is 1.6.Axial Sealing Device 1. Stuffing Box Sealing a. The fit between the stuffing box cover the stuffing box body is H11/d11, and the clearance between the cover hole and the shaft is 0.75-1.00mm (aft diameter 50-110mm), and the clearance between the agitator shaft and the body is 0.60-1.00mmshaft diameter 50-110mm). b. The end face clearance between the stuffing box cover and the body should be equal, and the error not exceed 0.3mm. c. The material and specification of the packing should be used correctly, with moderate length and width, and the lap joint of each of packing should be evenly staggered along the circumferential direction, with a lap joint angle of 30°, a flat cut surface, and the upper and lower parts be aligned. d. The packing should be left with appropriate margin for compression. e. The position of the oil ring should be accurate, and the oil passage be unobstructed. 2. Mechanical Seal a. The perpendicularity between the shaft and the sealing cavity is generally 0.05mm, and coaxiality with the sealing cavity is generally 0.5mm, the radial jump is 1mm, and the axial displacement is 1mm. b. The roughness of the shaft at the installation position of the mechanical seal should not be lower than 1.6. c. The sealing cavity should be kept clean, and surface roughness of the sealing surface of the dynamic and static rings should not be lower than 0.2, and it should not leak when filled with water. d The adjustment of the end pressure ratio should be appropriate, to ensure good lubrication and minimize leakage. Keep the sealing surface in a semi-liquid friction state. e. direction of the spring should be consistent with the working direction of the shaft. f. The perpendicularity of the static ring end face to the axis should not be greater than0.05mm. g. The dynamic ring of the installed mechanical seal should operate flexibly and reliably. h. When turning by hand, the sealing should turn smoothly without any abnormal phenomena. i. The air tightness test is qualified if no continuous small air bubbles are produced. Safety Accessories afety valves, burst discs, and pressure gauges shall be carried out in accordance with the relevant provisions for pressure vessels. Liquid Level Gauge Before installation use, the liquid level gauge should be subjected to a hydrostatic test at 1.5 times the nominal pressure of the liquid level gauge. The liquid level gauge should stopped and repaired or replaced under any of the following conditions: a. Exceeding the inspection cycle; b. The glass plate (tube) has cracks or; c. The valve is stuck; d. False liquid level often occurs. Other instruments, signal interlocking, safety devices, etc., should carried out in accordance with the relevant provisions.Installation a. The allowable horizontal error for the installation of the kettle body is 1mm/m. b. The allowable error for the installation elevation of the kettle body is ±5mm, and the allowable error for the position of the meridian and latitude: When the diameter is less than 1m, it is ±5mm; When the diameter is greater than 1m, it is ±8mm. . The distance between the pressure pipe, thermometer sleeve, heating coil, and the agitator shall not be less than 40mm. d. The deviation between two flanges should be less than 1mm, and the distance between the flange faces should be less than 2mm. Only one gasket is allowed between twoanges, and it is not allowed to use multiple gaskets to eliminate the defect of excessive distance between flange faces. e. The flange sealing surface shall be and free of mechanical damage, radial scratches, severe rust, weld scars, and residue of materials. The manhole cover plate shall be free of obvious deformation, rust, cracks and other defects. f. The sealing gasket must be installed correctly and coated with a thin layer of scaly graphite paint on both surfaces of the gasket. g. The nut on the bolt should rotate flexibly but not shake, and the thread should be clean. When tightening the flange, it is required to use a torque to tighten symmetrically and evenly in two to three times. The tightening force should not be excessive, insufficient, or uneven. h. It is not allowed to use bolts different materials and specifications on the same flange. i. For bolts that need to be tightened or cold tightened during the process of temperature rise or fall, the regulations must be followed. The reactor, as one of the key equipment in industrial production, its stable operation is essential. Through detailed inspection of the reactor and strict ad to various quality standards, not only can the product quality be guaranteed but also the service life of the equipment can be effectively extended, reducing the loss of downtime due to faults. Enter should formulate detailed maintenance plans, regularly carry out comprehensive inspections of the reactor, and ensure that the equipment is always in the best working condition.

Plaster patch, as a common external drug preparation, is favored for its convenient carrying, simple use and significant therapeutic effect. With the advancement of pharmaceutical technology, the production of plaster patches has been highly automated, with various equipment on the production line cooperating with each other to ensure the quality and production efficiency of plaster patches. Jinchong Enterprise will introduce in detail the main equipment of the plaster patch production line, including their structural composition, functional characteristics and working principles.      1. Raw Material Preparation Area 　　Functional features: The raw material preparation area is responsible for the preliminary processing raw materials for plasters, including steps such as weighing and mixing, to ensure the quality of raw materials required for subsequent processes. 　　Structural composition: This area mainly weighing devices, mixers, and other equipment. The weighing device usually uses a high-precision electronic scale, which can precisely control the weight of each component; the mixer fully integrates components through mechanical stirring. 　　Working principle: After the raw materials are weighed according to the formula ratio, they are added to the mixer, and the mechanical stirring method is to achieve uniform mixing, providing qualified raw materials for subsequent processes. 　　2. Base Material Preparation and Coating Equipment 　　Functional features: The base material and coating equipment are used to make the prepared raw materials into a paste-like base material and evenly coat it on the backing material. 　　Structural composition: The includes a heating and melting system, a coating head, and a cooling system. The heating and melting system is used to heat the solid base material to an appropriate fluidity; the head can precisely control the thickness of the base material coating; and the cooling system ensures rapid solidification after coating. 　　Working principle: The solid base material is evenly coated the backing material after being heated and melted and passing through the coating head, and then enters the cooling system for rapid solidification, forming a paste layer with certain adhesion. 　　3. Cutting and Shaping Equipment 　　Functional features: The cutting and shaping equipment is responsible for cutting the continuous production of paste into slices according to specifications and necessary shaping processing. 　　Structural composition: It mainly includes cutting knives, molding molds, and other components. The cutting knife can accurately cut the paste according to set size; the molding mold is used to make the shape of the plaster patch, such as round, square, etc. 　　Working principle: After the paste through the cutting knife and is cut into slices, it is then pressed into shape by the mold, ensuring that each plaster patch is consistent in size and neatly shaped.       4. Protective Film Application and Packaging Equipment 　　Functional features: This equipment is used to cover a layer of protective film on surface of plasters, and to complete the final product packaging. 　　Structural composition: It includes automatic film applying machines, packaging machines, etc. The automatic film applying can quickly and accurately adhere the protective film to the surface of the plaster; the packaging machine is responsible for placing the finished plasters into the corresponding packaging materials. 　　 principle: The film applying machine pastes the protective film on the surface of the plaster to prevent it from being contaminated during storage and transportation; the packaging machine seals the plas with the applied protective film for convenient sale and use. 　　Conclusion 　　The efficient operation of the plaster production line cannot be separated from the precise cooperation of the equipment in each link. From raw material preparation to final packaging, every step is crucial to ensure the high quality of the plaster products. With the development of technology, the pl production line in the future will become more intelligent and automated, further improving production efficiency and product quality.