Several major factor of affect the tablet press hardness

Jin Zong medicine tablet vendors would machine mainly in the production and r&d, Jin Zong small talk to everyone today affect hardness is the major factor of machine have? Tablet hardness are pressure were often encountered problems, affects the tablet with coating. Loose piece of main and grain quality, tablet machine operation has a close relationship. Grain quality is the key to good movies, therefore, granulating process for tablets quality is especially important. The influencing factors on the quality of the granule has the following several aspects: one is the influence of traditional Chinese medicine composition. Such as some Chinese herbal medicine contains a lot of fiber composition. Because of these medicinal herbs elasticity, viscosity, small, loose particles, low film hardness. To this, in practice can adopt appropriate solvent and methods, such effective components of medicinal materials to extract strong contraction, then granule preparation, in order to reduce the elastic particles, increase can be pressed, and then improve the tablet hardness; For medicinal materials containing fat volume, tablet is also easy to cause loose piece, if the oil belongs to the active ingredients, granulating absorbing agent should be added ( Such as calcium carbonate) To oil absorption, such as if the grease as invalid part, available squeezing or its he degreasing degreasing method, reduce the oil particles, increase its cohesion, thus improving the film hardness. The second is crushing degree of the influence of traditional Chinese medicine. If the Chinese herbal medicine powder is not fine, made of granular bondability, make the tablet loose easily. Powder to a certain fineness, therefore, this is the precondition of good particles, pressure good tablets. Three is the adhesive and the influence of wetting agents. Adhesive and wetting agent occupies an important position in the granulating, its breed selection and dosage is correct or not, directly affects the quality of particles. Select adhesive, wetting agents should depending on the nature of the powder, so all raw powder tabletting, should choose strong sticky glue, so full of tablet, and the resin more phlegmatic components in extract powder, you must choose more than 80% of the concentration of ethanol as a wetting agent. Glue dosage is too little, the fine powder particles is overmuch, can produce pine. Four is the impact of particles in the water. Particles in the water has a great influence on the tablet, just the right amount of water can increase the plastic deformation of brittle broken particles, reduce the elasticity, is helpful for tablet, elasticity, plasticity and dry particles small, hard to be pressed into. But if the moisture content is too high, also can make tablets, soft, sticky rushed or even blocking hopper, which affects tablet. The grain moisture content for each kind of traditional Chinese medicine tablet must be controlled in appropriate range. In addition, if caused by a lack of tablet during pressure, tablet machine running speed too fast, the length of the punch and appear loose phenomenon, can be appropriately adjusted pressure or slow down the speed, the replacement of the punch. Such as pressure and still appear loose enough phenomenon, should consider to other reasons, do not impose pressure, so as not to damage the tablet press.